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  1. 2024
  2. 01Kim D, Jeon HJ, Kwak Y, Lee SJ, Nam TG, Yu JH, An H, Hong KB Photocatalytic intermolecular bromonitroalkylation of stylenes: synthesis of cyclopropylamine derivatives and their evaluation as LSD1 inhibitors. RSC Advances. 2024, 14, 831-835.
  3. 2023
  4. 02Jeong K, Chang J, Park SM, Kim J, Jeon S, Kim DH, Kim YE, Lee JC, Im S, Jo Y, Min JY, Lee H, Yeom M, Seok SH, On DI, Noh H, Yun JW, Park JW, Song D, Seong JK, Kim KC, Lee JY, Park HJ, Kim S, Nam TG,* Lee W.* Rapid discovery and classification of inhibitors of coronavirus infection by pseudovirus screen and amplified luminescence proximity homogeneous assay. Antiviral Res. 2023, 209, 105473.
  5. 03Kim DH, Kim J, Lee H, Lee D, Im SM, Kim YE, Yoo M, Cheon YP, Bartz JC, Son YJ, Choi EK, Kim YS, Jeon JH, Kim HS, Lee S, Ryou C, Nam TG,* Synthesis and anti-prion aggregation activity of acylthiosemicarbazide analogues. J Enz Inhib Med Chem. 2023, 38(1), 2191164.
  6. 04Bae D, Chaudhary P, Been JH, Gautam J, Lee J, Shah S, Kim E, Lee H, Nam TG, Jeong BS, Kim JA,* Antitumor effect of 3-(quinolin-2-ylmethylene)-4,6-dimethyl-5-hydroxy-7-azaoxinidole down-regulating the Gas6-Axl axis. Eur J Med Chem. 2023, 251, 115274.
  7. 2022
  8. 05Jeon JH, Im S, Kim HS, Lee D, Jeong K, Ku JM, Nam TG,* Chemical chaperones to inhibit endoplasmic reticulum stress: Implications in diseases. Drug Des Devel Ther. 2022, 16, 4385-4397.
  9. 2021
  10. 06Kim YE, Kim DH, Choi A, Jang S, Jeong K, Kim YM, Nam TG,* Bi-aryl analogues of salicylic acids: Design, Synthesis and SAR study to ameliorate endoplasmic reticulum stress. Drug Des Devel Ther. 2021, 15, 3593-3604.
  11. 07Karmacharya U, Regmi SC, Awasthi BP, Chaudhary P, Kim YE, Lee IH, Nam TG,* Kim JA, Jeong BS. Synthesis and activity of N-(5-hydroxy-3,4,6-trimethylpyridin-2-yl)acetamide analogues as anticolitis agents via dual inhibition of TNF-α- and IL-6-induced cell adhesions Bioorg Med Chem Lett. 2021, 43, 128059.
  12. 08Lee H, Lee JS, Cho HJ, Lee YJ, Kim ES, Kim SK, Nam TG, Jeong BS, Kim JA. Antioxidant analogue 6-amino-2,4,5-trimethylpyridin-3-ol ameliorates experimental colitis in mice Dig Dis Sci. 2021, 66(4), 1022-1033.
  13. 09Lee H, Lee JS, Cho HJ, Lee YJ, Kim ES*, Kim SK, Nam TG, Jeong BS, Kim JA, Antioxidant analogue 6-amino-2,4,5-trimethylpyridin-3-ol ameliorates experimental colitis in Mice. Dig Dis Sci., 2021, 66(4), 1022-1033.
  14. 2020
  15. 10Lee SY, Kim CY, Nam TG*, Ruthenium complexes as anticancer agents: A brief history and perspectives. Drug Des Devel Ther., 2020, 14, 5375-5392
  16. 11Chaundhary CL, Chaundhary P, Dahal S, Dae D, Nam TG*, Kim JA*, Jeong BS*, Inhibition of colitis by ring-modified analogues of 6-acetamido-2,4,5-trimethylpyridin-3-ol. Bioorg Chem., 2020, 103, 104130
  17. 12Park SW, Kang HE, Yun W, Lee SY, Nam TG*, A facile synthesis of epinastine HCl via dehydroepinastine intermediate. Tetrahedron Lett., 2020, 61, 151451-151455
  18. 13Chaudhary CL, Gurung P, Jang S, Nam TG*, Kim JA*, Jeong BS*, Synthesis, activity and mechanism of alkoxy-, carbamato-, sulfonamide-, thioureido-, and ureido- derivatives of 2,4,5-trimethylpyridin-3-ol against inflammatory bowel disease. J Enzyme Inhib Med Chem., 2020, 35(1), 1-20
  19. 2019
  20. 14Choi H, Yun W, Lee J-H, Jang S. Park SW, Kim DH, Seon KP, Hyun J-M, Jeong K, Ku J-M, Nam TG*, Synthesis and anti-endoplasmic reticulum stress activity of N-substituted-2-arylcarbonylhydrazinecarbothioamides. Med Chem Res., 2019 , 28, 2142-2152
  21. 2018
  22. 15Oh Y J, Kim HY, Lee MH, Suh SH, Choi Y, Nam TG, Kwon WY, Lee SY, Yoo YH*, Cilostazol improves HFD-induced hepatic steatosis by upregulating hepatic STAMP2 expression through AMPK. Mol. Pharmacol., 2018 , 94(6), 1401-1411
  23. 16Gautam J, Banskota S, Chaudhary P, Dahal S, Kim DG, Kang HE, Lee IH, Nam TG, Jeong BS*, Kim JA*, Antitumor activity of BJ-1207, a 6-amino-2,4,5-trimethylpyridin-3-ol derivative, in human lung cancer, Chem. Biol. Interact., 2018, 294, 1-8
  24. 17Park SW, Banskota S, Gurung P, Jin YJ, Kang HE, Chaudhary CL, Lee SY, Jeong BS*, Kim JA*, Nam TG*, Synthesis and evaluation of 6-heteroarylamino-2,4,5-trimethylpyridin-3-ols as inhibitors of TNF-a-induced cell adhesion and inflammatory bowel disease, MedChemComm., 2018, 9, 1305-1310
  25. 18Park SW, Kim SH, Song J, Park GY, Kim D, Nam TG, Hong KB, Hypervalent iodine-mediated Ritter-type amidation of terminal alkenes: The synthesis of isoxazoline and pyrazoline cores, Beilstein J. Org. Chem., 2018, 14, 1028-1033
  26. 19Acharya S, Timilshina M, Jiang L, Neupane S, Choi DY, Park SW, Lee SY, Jeong BS, Kim JA, Nam TG, Chang JH, Amelioration of Experimental autoimmune encephalomyelitis and DSS induced colitis by NTG-A-009 through the inhibition of Th1 and Th17 cells differentiation, Sci. Rep., 2018, 8(1), 7799
  27. 20Bae D, Gautam J, Jang H, Banskota S, Lee SY, Jeong MJ, Kim AS, Kim HC, Lee IH, Nam TG, Kim JA, Jeong BS, Protective effects of 6-ureido/thioureido-2,4,5-trimethylpyridin-3-ols against 4-hydroxynonenal induced cell death in adult retinal pigment epithelial-19 cells. Bioorg, Med. Chem. Lett., 2018, 28(2), 107-112
  28. 2017
  29. 21Gautam J, Ku JM, Regmi SC, Jeong H, Wang Y, Banskota S, Park MH, Nam TG, Jeong BS, Kim JA, Dual inhibition of NOX2 and receptor tyrosine kinase by BJ-1301 enhances anticancer therapy efficacy via suppression of autocrine stimulatory factors in lung cancer, Mol. Cancer. Ther., 2017, 16(10), 2144-2156
  30. 22Gaire BP, Lee CH, Sapkota A, Lee SY, Chun J, Nam TG, Choi JW, Identification of Sphingosine 1-Phosphate Receptor Subtype 1 (S1P1) as a Pathogenic Factor in Transient Focal Cerebral Ischemia, Mol. Neurobiol., 2017, 16(10), 2144-2156
  31. 23Kang Y, Timilshina M, Nam TG, Jeong BS, Chang JH. BJ-1108, a 6-Amino-2,4,5-trimethylpyridin-3-ol analogue, regulates differentiation of Th1 and Th17 cells to ameliorate experimental autoimmune encephalomyelitis, Biol. Res., 2017, 50(1), 8
  32. 24Timilshina M, Kang Y, Dahal I, You Z, Nam TG, Kim KJ, Jeong BS, Chang JH. BJ-3105, a 6-Alkoxypyridin-3-ol analog, Impairs T cell Differentiation and prevents Experimental Autoimmune Encephalomyelitis Disease Progression, PLoS One, 2017, 21(1), e0168942.
  33. 2016
  34. 25Banskota S, Kang HE, Kim DG, Park SW, Jang H, Karmacharya U, Jeong BS, Kim JA, Nam TG, In vitro and in vivo inhibitory activity of 6-Amino-2,4,5-trimethylpyridin-3-ols against inflammatory bowel disease, Bioorg. Med. Chem. Lett., 2016, 26(19), 4586-4591
  35. 26Shah S, Lee C, Choi H, Gautam J, Jang H, Kim GJ, Lee YJ, Chaudhary CL, Park SW, Nam TG,* Kim JA,* Jeong BS* 5-Hydroxy-7-azaindolin-2-one, a novel hybrid of pyridinol and sunitinib: design, synthesis and cytotoxicity against cancer cells, Org. Biomol. Chem., 2016, 14, 4829-4841
  36. 27Gautam J, Banskota S, Regmi SC, Ahn S, Jeong YH, Jeong H, Kim SJ, Nam TG, Jeong BS, Kim JA, Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple negative breast cancer promote cancer progression through autocrine serotonin signaling, Mol. Cancer, 2016, 15(1), 75.
  37. 28Ku JM, Park K, Jeong DY, Cho KJ, Nam YJ, Lee JH, Kim YH, Kwon S, Park JY, Yang J, Nam TG, Yoon SH, Ahn S, Choi Y, Discovery, Optimization and Biological Evaluation of Sulfonamidoacetamides as an Inducer of Axon Regeneration, J. Med. Chem., 2016, 59(10), 4676-4687.
  38. 29Banskota S, Gautam J, Regmi SC, Gurung P, Park MH, Kim SJ, Nam TG, Jeong BS, Kim JA, BJ-1108, a 6-Amino-2,4,5-trimethylpyridin-3-ol Analog, Inhibits Serotonin-Induced Angiogenesis and Tumor Growth through PI3K/NOX Pathway, PLoSOne, 2016, 11(1), e0148133.
  39. 30Park SM, Choi J, Nam TG, Ku JM, Jeong K, Anti-Diabetic Effect of 3-Hydroxy-2-Naphthoic Acid, an Endoplasmic Reticulum Stress-reducing Chemical Chaperone, Eur. J. Pharmacol., 2016, 779, 157-167.
  40. 31Park SW, Choi H, Lee JH, Lee YJ, Ku JM, Lee SY, Nam TG, IBX-mediated synthesis of indazolone via Oxidative N-N Bond Formation and Unexpected Formation of Quinazolin-4-one: in situ Generation of Formaldehyde from Dimethoxyethane, Arch. Pharm. Res., 2016, 39(3), 302-309
  41. 32Lee SY, Baek NH, Nam TG Natural, Semisynthetic and Synthetic Tyrosinase inhibitors, J. Enz. Inh. Med. Chem., 2016, 31(1), 1-13
  42. 2014
  43. 33Lee H, Lee YK, Son MS, Nam TG, Jeong BS. Tocopherol Side Chain Synthesis via Asymmetric Organocatalytic Transfer Hydrogenation and Convenient Measurement of Stereoselectivity Tetrahedron Lett., 2014, 55, 5895-5897
  44. 34Lee H, Kim DG, Banskota S, Lee YK, Nam TG, Kim JA, Jeong BS. Pyridoxine-Derived Bicyclic Amido-, Ureido-, and Carbamato-Pyridinols: Synthesis and Antiangiogenic Activities, Org. Biomol. Chem., 2014, 12(43), 8702-8710
  45. 35Kadayat TM, Kim MJ, Nam TG, Park PH, Lee ES. Thieny/Furanyl-hydroxyphenylpropenones as inhibitors of LPS-induced ROS and NO production in RAW 264.7 macrophages, and their structure-activity relationship study Bull. Kor. Chem. Soc., 2014, 35(8), 2481-2486
  46. 36Lee CR, Lee SY, Nam TG. Succinct Synthesis of Bosentan by Utilizing Glycol Mono-THP ether Syn. Comm., 2014, 44(17), 2488-2493
  47. 37Lee HJ, Banskota S, Kim DK, Been JH, Jin YJ, Gautam J, Jang H, Nam TG, Kim JA, Jeong BS. Synthesis and Antiangiogenic Activity of 6-Amido-2,4,5-trimethylpyridin-3-ols, Bioorg. Med. Chem. Lett., 2014, 24(14), 3131-3136
  48. 38Kim DK, Kang Y, Lee H, Lee EK, Nam TG, Kim JA, Jeong BS. 6-Amino-2,4,5-Trimethylpyridin-3-ols: New General Synthetic Route and Antiangiogenic Activity Eur. J. Med. Chem., 2014, 78, 126-139
  49. ~2013
  50. 39Jeong, K, -w.; Ku, J.-m.; Park, M. -w.; Park, S. -m.; Yang, J. E. Nam, T. -G.* Hydroxynaphthoic Acids Identified in High Throughput Screening Potently Ameliorate Endoplasmic Reticulum Stress As Novel Chem. Pharm. Bull 2013, 61(7), 740-746
  51. 40Choi, Y.; Nam, T. -G.* Chemical Biology in Stem Cell Research Archives of Pharmacal Research 2012, 35(2), 281-297
  52. 41Meister. S.; Plouffe, D. M.; Kuhen K.; Bonamy, G. MC.; Wu, T.; Barnes, S. W.; Bopp, S. E.; Borboa, R.; Bright, A. T.; Che, J.; Cohen, S.; Dharia, N. V.; Gagaring, K.; Gettaycamin, M.; Gordon, P.; Groessl, Tl; Kato, N.; Lee, M. CS.; McNamara, C.; Fidock, D. A.; Nagle, A.; Nam, T. -G.; Richmond, W.; Roland, J.; Rottmann, M.; Zhou, B.; Froissard, P.; Glynne, R. J.; Mazier, D.; Sattabongkot, J.; Schultz, P. G.; Tuntland, T.; Walker, J. R.; Zhou, Y.; Chatterjee, A.; Diagana, T. T.; Winzeler, E. A.* Imaging of Plasmodium Liver Stages to Drive Next Generation Anti-Malarial. Drug Discovery Science, 2011, 334(6061), 1372-1377, Selected as Cover Story of the Issue.
  53. 4234 Nam, T.-G.; Ku, J. -M.; Rector, C. L.; Choi, H; Porter, N. A.*, Jeong, B. S.* Pyridoxine-Bicyclic Aminopyridinol Antioxidants; Synthesis and Their Antioxidant Activities Org. Biomol. Chem., 2011, 9, 8475-8482
  54. 43Nam, T.-G.; McNamara, C.; Bopp, S.; Dharia, N. V.; Meister, S.; Plouffe, D. M.; Kato, N.; Mccormack, S.; Bursulaya, B.; Ke, H.; Vaidya, A. B.; Schultz, P. G.*, Winzeler, E. A.* A chemical genomic analysis of decoquinate, a P. falciparum cytochrome B inhibitor ACS Chemical Biology 2011, 6(11), 1214-1222
  55. 44Nam, T.-G.; Lee, J.; Walker, J.; Brinker, A.; Cho, C. Y.; Schultz, P. G.* Identification and Characterization of Small Molecule Inducers of Fetal Hemoglobin ChemMedChem 2011, 6(5), 777-780
  56. 45Nam, T.-G. Lipid Peroxidation and Its Toxicological Implications Toxicological Research 2011, 27(1), 1-6
  57. 46Nam, T.-G.; Koo, J. M.; Park, H.-G.; Porter, N. A.*; Jeong, B. S.* New Synthetic Route to N-Tocopherol Derivatives: Synthesis of Pyrrolopyridinol Analogue of -Tocopherol from Pyridoxine Organic & Biomoecular Chemistry 2011, 9, 1749-1755
  58. 47Serwa, R.; Nam, T.-G. ; Valgimigli, L.; Culbertson, S.; Rector, C. L.; Jeong, B. -S.* Pratt, D. A.; Porter, N. A.* Preparation and Investigation of Vitamin B6 Derived Aminopyridinol Antioxidant equally contributed as co-first author, Chemistry -A European Journal 2010, 16(47), 14106-14114
  59. 48Omata, Y.; Saito, Y.; Yoshida, Y.; Jeong, B.-S.; Serwa, R.; Nam, T.-G.; Porter, N. A.; Niki, E.* Action of 6-Amino-3-Pyridinols Against Free Radicals and Oxidative Stress in Solution, Plasma, and Cultured Cells Free Radical Biology & Medicine 2010. 48(10),1358-1365
  60. 49Nam, T.-G.; Nara, S. J.; Zagol-Ikapitte, I.; Cooper, T.; Valgimigli, L.; Oates, J. A.; Porter, N. A.; Boutaud, O.*, Pratt, D. A.* Pyridine and pyrimidine Analogs of Acetaminophen as Inhibitors of Lipid Peroxidation and Cyclooxygenase and Lipoxygenase Catalysis Organic &. Biomolecular Chemistry 2009, 7(24), 5103- 5112, selected as Hot Article of the Issue
  61. 50Lee, J.; Hong, J.; Nam, T.-G.; Peters, E. C.; Orth, A. P.; Geierstanger, B. H.; Goldfinger, L. E.; Ginsberg, M. H.; Cho, C. Y.*; Schultz, P. G.* A Small Molecule Inhibitor of 4 Integrin-Dependent Cell Migration Bioorganic & Medicinal Chemistry 2009, 17(3), 977-988, Dedicated to the special issue for Professor Jonathan Ellman
  62. 51Plouffe, D.; Brinker, A.; McNamara, C.; Henson, K.; Kato, N.; Kuhen, K.; Nagle, A.; Adrian, F.; Matzen, J.; Anderson, P.; Nam, T.-G.; Gray, N. S.; Chatterjee, A.; Janes, J.; Yan, S. F.; Trager, R.; Caldwell, J. S.; Schultz, P. G.; Zhou, Y.; Winzeler, E. A.* In Silico Activity Profiling Reveals The Mechanism of Action of Antimalarials Discovered In an High- Throughput Screen Proceedings of National Academy of Sciences USA 2008, 105(26), 9059-9064
  63. 52Kang-Sickel, J. C.; Fox, D. D.; Nam, T.-G.; Jayaraj, K.; Ball, L. M.; French, J. E.; Klapper, D. G.; Gold, A.*, Nylander-French, L.* S- arylcysteine Adducts in Keratin as Biomarkers of Dermal Exposure to Aromatic Hydrocarbons Chemical Research in Toxicology 2008, 21(4), 852-858
  64. 53Nam, T.-G.; Rector, C. L.; Kim, H. Y.; Sonnen A. F.-P.; Meyer, R.; Nau, W. M.; Atkinson, J.; Rintoul, J.; Pratt, D. A.* Porter, N. A.* Tetrahydro-1,8-Naphthyridinol Anlogues of -Tocohperol as Antioxidants in Lipid Membranes and Low Density Lipoproteins Journal of the American Chemical Society 2007, 129, 10211-10219
  65. 54Nam, T.-G.; Wijtmans, M.; Pratt, D. A.*, Porter, N. A.* Regioselective addition of n- alkyllithiums to α, α’-disubstituted-1,8-naphthyridines: Synthesis of 6- amino-3-pyridinol analogs of α-tocopherol Synthsis 2005, 9, 1397-1404, Dedicated to the special issue for Professor Bernd Giese
  66. 55Gold, A,*; Nam, T.-G,. Jayaraj, K.; Sangaiah, R.; Kalpper, D. G.; Ball, L. M.; French, J. E.; Nylander-French, LA. Synthesis of S-aryl-DL-Cysteines and Incorporation into Keratin Sequences Organic Preparations & Procedures International 2003, 35(4), 375-382
  67. 56Nam, T.-G.; Sangaiah, R.; Gold, A.*; Lacks, G, D.; French, J. E.; Nylander-French, L. A. Synthesis of FMoc-Protected S-Arylcysteines and Modified Keratin Sequence Peptides as Specific Epitopes as Immunogens Polycyclic Aromatic Compounds 2002, 22(3-4), 239-248
  68. 57Jew, S. S.*; Lim, D.; Seo, S.; Nam, T.-G.; Park, H.; Kim, C.; Lee, M.; Paik, H.; Lee, M.; Jung, Y. Regioselective ring opening of steroidal epoxide with hydrides: formation of C(2)- and C(3)- deoxyasiatic acid derivatives Archives of Pharmacal Research 1998, 21(6), 793-795
  69. 58Jew, S.S.*, Lim, D.Y.; Seo, S. K.; Nam, T.-G.; Park, H. G.; Kim, H. D.; Kim, C, M.; Lee, M. H.; Paik, H. G.; Lee, M. J.; Jung, Y. H. Formation of methyl 2, 3-epoxy-23-hydroxyurs-12-en-28-oate from asiaticoside and its reductive epoxide ring opening reaction Yakhak Hoechi 1998, 42(5): 500-506

Patents

  1. 01Preparation of 6-aminopyridin-3-ol derivatives for the treatment of disease caused by angiogenesis. PCT Appl. (2013), WO 2013095060 A1 20130627
  2. 02Anticancer supplement including undecylenic acid, conjugated linoleic acid and/or a conjugated linoleic acid isomer. PCT Appl. (2012), Wo 2012026663 A1 20120301
  3. 03Bicyclic pyridinol derivatives for preventing or treating diseases caused by angiogenesis. PCT Appl. (2013), Wo 2013085340 A1 20130613
  4. 04Preparation of 6-aminopyridin-3-ol derivatives for the treatment of disease caused by angiogenesis. PCT Appl. (2013), WO 2013095060 A1 20130627
  5. 05Preparation of amidopyridinol derivatives having antiangiogenic effect. PCT Int. Appl. (2014), WO 201417180 A1 20141023
  6. 06아시아트산의 제조방법 KR-0325268 (2002. 02. 06 등록)
  7. 07세프티오퍼 합성에 유용한 중간체 및 이를 이용한 세프티오퍼의 제조 방법 KR-0355115 (2002. 09. 19 등록)
  8. 08심바스타틴의 제조방법 KR-0361833 (2002. 11. 07등록)
  9. 09아시아트산 유도체를 유효성분으로 하는 치매 및 인식장애 치료제 (Medicines for Treating Dementia of Cognitve Disorder, Which comprises Asiatic Acid Derivatives), US-6169112 (2001. 01. 02등록), EP-0944571 (2001. 06. 13 등록)
  10. 10아시아트산 유도체, 그의 제조방법 및 이를 함유하는 창상치료제 (Asiatic acid Derivatives : Its Manufacturing Method and Dermatological Agents Containing It) KR-0169547 (1998. 10. 12 등록), CN-1067976 (2001. 07. 04등록), GB-2309695 (1997. 08. 06등록), FR-2727678 (1998. 06. 19등록).
  11. 11아시아트산의 제조방법 KR-0325268 (2002. 02. 06 등록)
  12. 12세프티오퍼 합성에 유용한 중간체 및 이를 이용한 세프티오퍼의 제조 방법 KR-0355115 (2002. 09. 19 등록)
  13. 13심바스타틴의 제조방법 KR-0361833 (2002. 11. 07등록) 남태규 외 2인.
  14. 14아시아트산 유도체를 유효성분으로 하는 치매 및 인식장애 치료제 (Medicines for Treating Dementia or Cognitve Disorder, Which comprises Asiatic Acid Derivatives), US-6169112 (2001. 01. 02등록), EP-0944571 (2001. 06. 13 등록) 주상섭외 16인.
  15. 15아시아트산 유도체, 그의 제조방법 및 이를 함유하는 창상치료제 (Asiatic acid Derivatives : Its Manufacturing Method and Dermatological Agents Containing It) KR-0169547 (1998. 10. 12 등록), CN-1067976 (2001. 07. 04등록), GB-2309695 (1997. 08. 06등록), FR-2727678 (1998. 06. 19등록). 주상섭외 9인.
  16. 16A환이 변형된 아시아트산 유도체 KR-1998-0042830 (1998. 08. 17 출원) 주상섭 외 18인.
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